Protein GLI2 map

Identifiers
HUGO:GLI12

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
CASCADE:TGFB
CASCADE:HH
PMID:17638910; PMID:22354771
GLI1, GLI2, GLI3 proteins are expressed in fibroblasts, GLI1 and GLI2 expression is upregulated by TGFB via SMAD3
Double-staining for ??-SMA and GLI1 or GLI2 demonstrated a prominent accumulation of both GLI transcription factors in myofibroblasts
PMID:19081070
The vertebrate GliRepressor function is largely derived from Gli3 while the primary GliActivator activity is largely contributed by Gli2. Gli1 is a transcriptional target of Hh signaling and acts as a transcriptional activator to reinforce GliA function
PMID:23031257
TGF-??1???Induced Fibroblast Differentiation Depends on SMO in Control Fibroblasts
Expression of collagen and actin (alphaSMA) and FN1 are SMO and GLI1/GLI2 dependent

Modifications:
In compartment: Cytosol
  1. GLI2@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rGLI2@Cytosol map → map GLI2@Cytosol map
    As Catalyser:
    1. gCollagens*@Cytosol map → map rCollagens*@Cytosol map
    2. gPTCH*@Cytosol map → map rPTCH*@Cytosol map
    3. gACTA2@Cytosol map → map rACTA2@Cytosol map
    4. gFN*@Cytosol map → map rFN*@Cytosol map