Protein SOD2 map

Identifiers
HUGO:SOD2
superoxide dismutase 2, mitochondrial
HUGO:SOD2 HGNC:11180 ENTREZ:6648 UNIPROT:P04179

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / METABOLIC  map
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

References
PMID:22850421; PMID:21358671
SIRT3 is involved in the control of HIF1 expression, and redox signaling.
A decrease in SIRT3 expression leads to increased superoxide dismutase 2 (SOD2) acetylation/inhibition, thereby causing ROS increase and HIF1 stabilization.
SIRT3 is upregulated in normal fibroblasts and downregulated in CAFs.
PMID:21150282
the tumor promoting effects of Cav-1 deficient fibroblasts could be functionally suppressed (nearly 2-fold) by the recombinant over-expression of SOD2 (superoxide dismutase 2), a known mitochondrial enzyme that de-activates superoxide, thereby reducing mitochondrial oxidative stress. I

SOD2@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

Modifications:
In compartment: Cytosol
  1. SOD2@Cytosol map
  2. SOD2|​ace@Cytosol map
In compartment: Mitochondrial Matrix
  1. SOD2@Mitochondrial Matrix map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SOD2|​ace@Cytosol map → map SOD2@Cytosol map
    2. rSOD2@Nucleus map → map SOD2@Mitochondrial Matrix map
    As Catalyser:
    1. O_sub_2_endsub__super_-_endsuper_@Cytosol map → map H_sub_2_endsub_O_sub_2_endsub_@Cytosol map
    2. O_sub_2_endsub__super_-_endsuper_@Mitochondrial Matrix map → map O_sub_2_endsub_@Mitochondrial Matrix map + H_sub_2_endsub_O_sub_2_endsub_@Mitochondrial Matrix map