Protein IDH3A map

Identifiers
HUGO:IDH3A
isocitrate dehydrogenase 3 (NAD+) alpha
HUGO:IDH3A HGNC:5384 ENTREZ:3419 UNIPROT:P50213

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
 RECON2  map

References
CASCADE:TGFB
MUDULE:METABOLIC
PMID:25732824
CAFs from tumor samples exhibit low levels of IDH3??, and overexpression of IDH3?? prevents transformation of fibroblasts into CAFs.
DH3A downregulation occurred mainly through transcriptional regulation downstream of TGFB
IDH3A converts isocitrate into alpha-KG
The activity of PHD requires oxygen and alpha-KG

IDH3A@Mitochondrial Matrix

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map

Modifications:
In compartment: Cytosol
  1. IDH3A@Cytosol map
In compartment: Mitochondrial Matrix
  1. IDH3A@Mitochondrial Matrix map
Participates in complexes:
In compartment: Mitochondrial Matrix
  1. IDH3A|​hm2:​IDH3B:​IDH3C:​Mg2+@Mitochondrial Matrix map
Participates in reactions:
As Reactant or Product:
  1. IDH3A@Cytosol map → map NEGATIVE_REGULATORS OF_CAF@Cytosol map
  2. rIDH3A@Cytosol map → map IDH3A@Cytosol map
  3. rIDH3A@Nucleus map → map IDH3A@Mitochondrial Matrix map
  4. IDH3A@Mitochondrial Matrix map + IDH3B@Mitochondrial Matrix map + IDH3C@Mitochondrial Matrix map + Mg2+@Mitochondrial Matrix map → map IDH3A|​hm2:​IDH3B:​IDH3C:​Mg2+@Mitochondrial Matrix map
As Catalyser:
  1. piruvat@Cytosol map → map TCA_CYCLE@Cytosol map
  2. isocitrate@Cytosol map → map Alpha_ketoglutarate@Cytosol map
  3. isocitrate@Mitochondrial Matrix map + H+@Mitochondrial Matrix map + NAD_super_+_endsuper_@Mitochondrial Matrix map → map 2-oxoglutarate@Mitochondrial Matrix map + CO_sub_2_endsub_@Mitochondrial Matrix map + NADH@Mitochondrial Matrix map