Identifiers
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627
HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A
DYRK, DYRK1, MNBH
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / HEDGEHOG
Survival / PI3K_AKT_MTOR
Survival / WNT_NON_CANONICAL
References
PMID:11980723
PMID:19685005
Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / CASPASES
References
rc_re498( Regulated Cell Death ):
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38
References
s_akt2_re122:( Survival ) PMID:11980723
s_wnc2_re56( Survival ):
DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol
PMID:16511445
su_shh1_s_shh2_re7:( Survival ) PMID:12138125
References
s_shh2_re7:( Survival ) PMID:12138125
→ Caspase9*|S196_unk|T125_pho|S144_unk|Y153_unk@Cytosol
→ FOXO1|T24_pho|S322_pho|S256_pho|S319_pho|S325_pho|S329_pho@Nucleus
+ GLI1|pho|pho@Nucleus → GLI1|pho|pho:promoter_region@Nucleus
→ GLI1|pho|pho@Nucleus
→ NFAT*|pho|pho@Nucleus