Protein ECSIT map

Identifiers
ECSIT homolog (Drosophila)
HUGO:ECSIT HGNC:29548 ENTREZ:51295 UNIPROT:Q9BQ95
HUGO:ECSIT

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / MITOCHONDRIAL_GENES  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map

References
 MACROPHAGE  map
CASCADE:TLR2_4
PMID:25371197,
TAK1-ECSIT-TRAF6 Complex Plays a Key Role in the TLR4 Signal to Activate NF-??B
ECSIT-knockdown monocytic cells exhibited severe impairments in NF-??B activity, cytokine production, and NF-??B-dependent gene expression, whereas those were dramatically restored by reintroduction of wild type (WT) ECSIT gene.
IRF7, IL-1??, CD44, NF-??B2, IER3, IL-8, NF-??B1A, and RelB were markedly decreased in the ECSITKD
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-??B
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.

Modifications:
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ECSIT@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Mitochondrial inner membrane
  1. ACAD9:​ECSIT:​NDUFAF1@Mitochondrial inner membrane map
Participates in reactions:
As Reactant or Product:
  1. ECSIT@INNATE_IMMUNE_CELL_Cytosol map → map ECSIT@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  2. MAP3K1@INNATE_IMMUNE_CELL_Cytosol map → map MAP3K1@INNATE_IMMUNE_CELL_Cytosol map
  3. degraded + NDUFS8@Mitochondrial inner membrane map + MT-ND5@Mitochondrial inner membrane map + MT-ND4@Mitochondrial inner membrane map + MT-ND4L@Mitochondrial inner membrane map + MT-ND3@Mitochondrial inner membrane map + MT-ND2@Mitochondrial inner membrane map + MT-ND1@Mitochondrial inner membrane map + MT-ND6@Mitochondrial inner membrane map → map FMN:​MT-ND1:​MT-ND2:​MT-ND3:​MT-ND4:​MT-ND4L:​MT-ND5:​MT-ND6:​NDUFA1:​NDUFA10:​NDUFA11:​NDUFA12:​NDUFA13:​NDUFA2:​NDUFA3:​NDUFA4:​NDUFA5:​NDUFA6:​NDUFA7:​NDUFA8:​NDUFA9:​NDUFAB1:​NDUFB1:​NDUFB10:​NDUFB11:​NDUFB2:​NDUFB3:​NDUFB4:​NDUFB5:​NDUFB6:​NDUFB7:​NDUFB8:​NDUFB9:​NDUFC1:​NDUFC2:​NDUFS1|​[2Fe-2S],[4Fe-4S],[4Fe-4S]:​NDUFS2:​NDUFS3:​NDUFS4:​NDUFS5:​NDUFS6:​NDUFS7|​[4Fe-4S]:​NDUFS8|​[4Fe-4S],[4Fe-4S]:​NDUFV1|​[4Fe-4S]:​NDUFV2|​[2Fe-2S]:​NDUFV3@Mitochondrial inner membrane map