Phenotype Necrosis death map
Necrosis death@Cytosol

References
PMID:27558815
PMID:27048813
PMID:27959630
Necroptosis is a form of regulated cell death that critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and generally manifests with morphological features of necrosis.
PMID:26853145
Sequential Engagement of Distinct MLKL Phosphatidylinositol-Binding Sites Executes Necroptosis.
PMID:28498367
rc_re1805( Regulated Cell Death  map ):
PMID:27646922
Excess cellular levels of ROS cause damage to proteins, nucleic acids, lipids, membranes and organelles, which can lead to activation of cell death processes such as apoptosis.

Modifications:
In compartment: Cytosol
  1. Necrosis death@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Lysosome Membrane Permeabilization@Cytosol map → map Necrosis death@Cytosol map
    2. ROS Production@Cytosol map → map Necrosis death@Cytosol map
    3. Mitochondrial fission@Cytosol map → map Necrosis death@Cytosol map
    4. PARP activation@Cytosol map → map Necrosis death@Cytosol map
    5. NAD and ATP depletion@Nucleus map → map Necrosis death@Cytosol map
    6. AKT*|​S473_pho|​T308_pho@Cytosol map → map Necrosis death@Cytosol map
    7. Ceramide@Cytosol map → map Necrosis death@Cytosol map
    8. Ca2+ Wave@Cytosol map → map Necrosis death@Cytosol map
    As Catalyser: