Identifiers
Collagen 1*
collagen, type I, alpha 1
HUGO:COL1A1 HGNC:2197 ENTREZ:1277 UNIPROT:P02452
collagen, type I, alpha 2
HUGO:COL1A2, HGNC:2198, ENTREZ:1278, GENECARDS:GC07P094023, UNIPROT:P08123??
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CELL_MATRIX_ADHESIONS
EMT Senescence / ECM
References
PMID:18375391
Type I procollagen is a heterotrimer composed of 2 proalpha1(I) chains (encoded by COL1A1) and 1 proalpha2(I) chain (encoded by COL1A2 genes)
proalpha2(I) C-propeptide and proalpha1(I) C-propeptide, is essential for efficient assembly of type I procollagen heterotrimers.
PMID:17217948
Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGFB2 in human retinal pigment epithelial cells
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression
References
em_emtc_emtc_re904( EMT Senescence ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
+ Collagen1 partners*@Extracellular space → Collagen1 partners*:Collagen1*@Extracellular space
→ Cell-matrix adhesions@Extracellular space
→ Truncated Collagen1*@Extracellular space
→ COL1A2@Extracellular space
→ COL1A1@Cytosol
+ Collagen1*@Extracellular space → Collagen1*:a1b1*_a2b1*@Extracellular space
→ Cell-matrix adhesions@Extracellular space