Protein COL1A2 map

Identifiers
collagen, type I, alpha 2
HUGO:COL1A2, HGNC:2198, ENTREZ:1278, GENECARDS:GC07P094023, UNIPROT:P08123??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map
 EMT Senescence  map  / ECM  map

References
PMID:18375391
Type I procollagen is a heterotrimer composed of 2 proalpha1(I) chains (encoded by COL1A1) and 1 proalpha2(I) chain (encoded by COL1A2 genes)
proalpha2(I) C-propeptide and proalpha1(I) C-propeptide, is essential for efficient assembly of type I procollagen heterotrimers.
PMID:17217948
Inhibition of RhoA/Rho-kinase pathway suppresses the expression of type I collagen induced by TGFB2 in human retinal pigment epithelial cells
PMID:11114293
Sp1 and Smad proteins form complexes and their synergy plays an important role in mediating TGFB1-induced 2(I) collagen expression in human mesangial cells.
Involvement of Sp1 binding in Smad3-mediated TGFB1 induction of COL1A2
Sp1 and Smad proteins bind to the COL1A2 promoter
TGFB1 increases association between Sp1 and Smad proteins
Sp1 and Smad3 cooperate to regulate COL1A2 expression

Modifications:
In compartment: Cytosol
  1. COL1A2@Cytosol map
In compartment: Extracellular space
  1. COL1A2@Extracellular space map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rCOL1A2@Nucleus map → map COL1A2@Cytosol map
    2. COL1A2@Cytosol map → map COL1A2@Extracellular space map
    3. Collagen1*@Extracellular space map → map COL1A2@Extracellular space map
    As Catalyser: