Protein EPHA2 map

Identifiers
EPH receptor A2
"EphA2"
HUGO:EPHA2 HGNC:3386 ENTREZ:1969 UNIPROT:P29317

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:20179713
E-cadherin promotes EPHA2??? ephrin-A1 localization at epithelial cell junctions
EPHA2 is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis.
EPHA2 seems to be preferentially expressed in malignant breast and prostate cancers with a basal phenotype.
EPHA1 is downregulated in advanced human skin and colorectal cancers, EphB receptors are downregulated in advanced colorectal cancer and ephrin-A5 is downregulated in glioblastomas
TNF-alpha, VEGFA and HIF2A upregulate ephrin-A1 in cultured endothelial cells.
Endothelial ephrin-B2 is upregulated by VEGF through the Notch pathway.
PMID:19074825

Modifications:
In compartment: Cytosol
  1. EPHA2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. EPHA2|​pho|​hm2:​Epherin-A1*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. EPH family*@Cytosol map → map EPHA2@Cytosol map
  2. EPHA2@Cytosol map + Epherin-A1*@Extracellular space map → map EPHA2|​pho|​hm2:​Epherin-A1*@Cytosol map
As Catalyser: