Protein EPHB2 map

Identifiers
EPH receptor B2
"EphB2"
HUGO:EPHB2 HGNC:3393 ENTREZ:2048 UNIPROT:P29323

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / ECM  map

References
PMID:20179713
E-cadherin promotes EPHA2??? ephrin-A1 localization at epithelial cell junctions
EPHA2 is upregulated in many cancers and its expression has been linked to increased malignancy and a poor clinical prognosis.
EPHA2 seems to be preferentially expressed in malignant breast and prostate cancers with a basal phenotype.
EPHA1 is downregulated in advanced human skin and colorectal cancers, EphB receptors are downregulated in advanced colorectal cancer and ephrin-A5 is downregulated in glioblastomas
TNF-alpha, VEGFA and HIF2A upregulate ephrin-A1 in cultured endothelial cells.
Endothelial ephrin-B2 is upregulated by VEGF through the Notch pathway.

Modifications:
In compartment: Cytosol
  1. EPHB2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. EPHB2|​pho|​hm2:​Ephrin-B1*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. EPH family*@Cytosol map → map EPHB2@Cytosol map
  2. EPHB2@Cytosol map + Ephrin-B1*@Extracellular space map → map EPHB2|​pho|​hm2:​Ephrin-B1*@Cytosol map
As Catalyser: