Protein LIMK1_2* map

Identifiers
LIMK1_2*
LIM domain kinase 1
HUGO:LIMK1, HGNC:6613, ENTREZ:3984, UNIPROT:P53667, GENECARDS:GC07P073497
LIM domain kinase 2
HUGO:LIMK2 HGNC:6614 ENTREZ:3985 UNIPROT:P53671

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

LIMK1_2*@Cytosol

References
em_emtc_emtc_re471( EMT Senescence  map ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:15866889
The ARP2_3 complex and Cofilin are involved in protrusion at the leading edge: the actin-severing activity of cofilin and the actin-branching activity of Arp2_3 act in synergy to drive the extension of lamellipodia.
Cofilin is also required for the maintenance of a polarized cytoskeleton and thus for directional cell migration.
Integrins control motile strategy through a Rho-cofilin pathway.
Adhesion to fibronectin by a5b1 integrin leads to phosphorylation and thus inactivation of cofilin.
Cells thus fail to polarize their cytoskeleton but extend thin protrusion with cell-matrix adhesions in multiple directions.

Modifications:
In compartment: Cytosol
  1. LIMK1_2*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LIMK1_2*@Cytosol map → map LIMK1|​pho|​active@Nucleus map
    2. LIMK1_2*@Cytosol map → map LIMK2|​pho|​active@Cytosol map
    As Catalyser:
    1. CFL1@Cytosol map → map CFL1|​pho@Cytosol map
    2. DSTN@Cytosol map → map DSTN|​pho@Cytosol map