Identifiers
HUGO:LMK1
HUGO:LIMK1
LIM domain kinase 1
HUGO:LIMK1, HGNC:6613, ENTREZ:3984, UNIPROT:P53667, GENECARDS:GC07P073497
Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
Adaptive Immune Response / TCR_SIGNALING
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
EMT Senescence / SENESCENCE
Innate Immunity / IMMUNOSTIMULATORY_CORE_PATHWAYS
References
PMID:9655398
PMID:11698448 PMID:10652353
PMID:21178402
Activation of LIMK by ROCK has been linked to the phosphoregulation of ADF/cofilin.52,54???56 ADF/cofilin has been shown to be one of the key regulators of actin severing, nucleation and capping within the protrusive machinery
NATURAL_KILLER
PMID:11698448
LIMK1 is a serine/threonine kinase that phosphorylates and inactivates the actin-depolymerization factor cofilin, thereby regulating actin cytoskeletal reorganization.
FcR-initiated LIMK1 phosphorylation was absent in the NK clones that had been treated with p160ROCK kinase inhibitor.
Inhibition of the RhoA/p160ROCK/LIMK1 signaling pathway abrogates lipid raft polarization to the effector-target interface
References
em_emtc_emtc_re472( EMT Senescence ):
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:11018042
LIMK1 is regulated by Pak1,