Protein DSTN map

Identifiers
destrin (actin depolymerizing factor)
HUGO:DSTN HGNC:15750 ENTREZ:11034 UNIPROT:P60981

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map

DSTN@Cytosol

References
em_emtc_emtc_re850( EMT Senescence  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

DSTN|​pho@Cytosol

References
em_emtc_emtc_re850( EMT Senescence  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

Modifications:
In compartment: Cytosol
  1. DSTN@Cytosol map
  2. DSTN|​pho@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. DSTN@Cytosol map → map DSTN|​pho@Cytosol map
    2. DSTN@Cytosol map + Actin cytoskeletal*@Cytosol map → map em_emtc_emtc_s3022
    As Catalyser: