Protein LIMK2 map

Identifiers
HUGO:LMK2
LIM domain kinase 2
HUGO:LIMK2 HGNC:6614 ENTREZ:3985 UNIPROT:P53671

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:9655398

LIMK2|​pho|​active@Cytosol

References
em_emtc_emtc_re847( EMT Senescence  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

Modifications:
In compartment: Cytosol
  1. LIMK2@Cytosol map
  2. LIMK2|​pho|​active@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. LIMK2@Cytosol map → map LIMK*@Cytosol map
    2. LIMK2@Cytosol map → map LIMK2|​pho|​active@Cytosol map
    3. LIMK1_2*@Cytosol map → map LIMK2|​pho|​active@Cytosol map
    As Catalyser: