Phenotype Lysosome Membrane Permeabilization map
Lysosome Membrane Permeabilization@Cytosol

References
PMID:18955971
PMID:23788428
Lysosomal membrane permeabilization in cell death.
Lysosomal membrane permeabilization (LMP) causes the release of cathepsins and other hydrolases from the lysosomal lumen to the cytosol
rc_re1581( Regulated Cell Death  map ):
PMID:22454477
Sphingosine mediates TNF??-induced lysosomal membrane permeabilization and ensuing programmed cell death in hepatoma cells.
rc_re1622( Regulated Cell Death  map ):
PMID:15659826
Increased expression and translocation of lysosomal cathepsins contribute to macrophage apoptosis in atherogenesis
rc_re1617( Regulated Cell Death  map ):
LMP causes the proteolytic activation of Bid (which is cleaved by the two lysosomal cathepsins B and D), which then induces MOMP
PMID:16966373
PMID:17670831
rc_re1618( Regulated Cell Death  map ):
PMID:11427496

Modifications:
In compartment: Cytosol
  1. Lysosome Membrane Permeabilization@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Lipid hydroperoxides@Cytosol map → map Lysosome Membrane Permeabilization@Cytosol map
    2. Hydroxyl radical@Lysosome map → map Lysosome Membrane Permeabilization@Cytosol map
    3. Sphingosine@Lysosome map → map Lysosome Membrane Permeabilization@Cytosol map
    4. BAX@Lysosome map → map Lysosome Membrane Permeabilization@Cytosol map
    5. Lysosome Membrane Permeabilization@Cytosol map → map Necrosis death@Cytosol map
    As Catalyser:
    1. CTSB@Lysosome map → map CTSB@Cytosol map
    2. CTSD@Lysosome map → map CTSD@Cytosol map