Protein CTSD map

Identifiers
cathepsin D
HUGO:CTSD HGNC:2529 ENTREZ:1509 UNIPROT:P07339
HUGO:CTSD

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
PMID:22439866
Several components of ECM, such as fibronectin, proteoglycans, and collagens, are substrates for CTSD(cathepsin D)
PMID:18955971
 DENDRITIC_CELL  map
PMID:16237087
CTSD (aspartic cathepsin D) and CTSG (cathepsin G) participate in antigen processing in DC.
PMID:12776207
Cathepsins B,D,L, S and AEP (LGMN) are the lysosomal proteases implicated in antigen presentation in DC.

CTSD@Lysosome

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map

References
rc_re1618( Regulated Cell Death  map ):
PMID:18955971
LMP causes the proteolytic activation of Bid (which is cleaved by the two lysosomal cathepsins B and D), which then induces MOMP
PMID:16966373
PMID:17670831
PMID:11427496

Modifications:
In compartment: Cytosol
  1. CTSD@Cytosol map
In compartment: Lysosome
  1. CTSD@Lysosome map
In compartment: PHAGOSOME/ENDOSOME/LYSOSOME_Membrane
  1. CTSD@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rCTSD@Nucleus map → map CTSD@Cytosol map
    2. CTSD@Cytosol map → map Invadopodia@Cytosol map
    3. CTSD@Lysosome map → map CTSD@Cytosol map
    4. CTSD@Cytosol map → map Cathepsin*@Cytosol map
    As Catalyser:
    1. Tumor_antigen@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map → map Tumor_antigen_fragment@PHAGOSOME/ENDOSOME/LYSOSOME_Membrane map
    2. BID@Cytosol map → map cleaved_BID*@Cytosol map