Simple molecule lysophostatidic acid map
lysophostatidic acid@default

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_SIGNALING_PATHWAYS  map

References
PMID:21674557
Tumor-secreted lysophostatidic acid accelerates hepatocellular carcinoma progression by promoting differentiation of peritumoral fibroblasts in myofibroblasts.
This effect is mediated by up-regulation of specific genes related to a myo/contractile phenotype (ACTA2, CNN1,FN (ED-A containing), EDN1, MYL12A, TAGLN2) and inhibition of ACTG2 expression.
LPA induces fibroblast proliferation.

Modifications:
In compartment: default
  1. lysophostatidic acid@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. lysophostatidic acid@default map → map Fibroblast_proliferation@Cytosol map
    As Catalyser:
    1. gMYL12A@Cytosol map → map rMYL12A@Cytosol map
    2. gEDN1@Cytosol map → map rEDN1@Cytosol map
    3. gTAGLN2@Cytosol map → map rTAGLN2@Cytosol map
    4. gACTA2@Cytosol map → map rACTA2@Cytosol map
    5. gCNN1@Cytosol map → map rCNN1@Cytosol map
    6. gFN*@Cytosol map → map rFN*@Cytosol map
    7. gACTG2@Cytosol map → map rACTG2@Cytosol map