Protein CTGF map

Identifiers
connective tissue growth factor
HUGO:CTGF hgnc_id:HGNC:2500 HGNC:2500 ENTREZ:1490 UNIPROT:P29279

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map

References
CASCADE:TGFB
PMID:23259531
CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis.
PMID:11013125 ; PMID:11376132
CTGF expression is induced by TGF- beta in fibroblasts via SMAD3 and SMAD4 pathway
PMID:15003992
TGF-?? induced the myofibroblast phenotype via a CTGF-dependent pathway,
CTGF mediates EGF-stimulated proliferation and IGF-2-induced differentiation of fibroblasts,
probably via activation of EGFR and IGFR.

Modifications:
In compartment: Cytosol
  1. CTGF@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CTGF@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
    2. CTGF@Cytosol map → map CTGF@Cytosol map
    3. rCTGF@Cytosol map → map CTGF@Cytosol map
    4. CTGF@Cytosol map → map Fibroblast_proliferation@Cytosol map
    As Catalyser:
    1. EGFR@Cytosol map + ERBB*@Cytosol map → map EGFR:​ERBB*@Cytosol map