Protein ELC_MYOSIN_II* map

Identifiers
HUGO:MYL6 HUGO:MYL6B
myosin light chain 6
HUGO:MYL6 hgnc_id:HGNC:7587 HGNC:7587 ENTREZ:4637 UNIPROT:P60660
myosin light chain 6B
HUGO:MYL6B hgnc_id:HGNC:29823 HGNC:29823 ENTREZ:140465 UNIPROT:P14649

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map

References
PMID:25712372 PMID:19349987
PMID:25712372
In mammals,
three genes (MYH9, MYH10, MYH14) encode for three
non-muscle myosin-2 isoforms referred to as -2A, -2B, and -
2C, respectively. Most cells simultaneously express two or
three non-muscle myosin-2 paralogs and their splice variants
in a strictly regulated manner. Each mammalian non-muscle
myosin-2 heavy chain associates with one ELC encoded by
one of two genes (MYL6, MYL6B) and with one RLC
encoded by either MYL9, MYL12A, or MYL12B
 MACROPHAGE  map
CASCADE:CR3

Modifications:
In compartment: Cytosol
  1. ELC_MYOSIN_II*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. ELC_MYOSIN_II*@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*@Cytosol map
  2. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*|​pho@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
  2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@T_cell map
  2. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@T_cell map
  3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@T_cell map
Participates in reactions:
As Reactant or Product:
  1. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@T_cell map + WASP*|​Tyr291_pho:​WIPF1|​pho@T_cell map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@T_cell map
  2. ELC_MYOSIN_II*@T_cell map + RLC_MYOSIN_II*@T_cell map + MYH9|​hm2@T_cell map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@T_cell map
  3. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@T_cell map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@T_cell map
  4. ELC_MYOSIN_II*@Cytosol map + RLC_MYOSIN_II*@Cytosol map + MYH*|​hm2@Cytosol map → map ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*@Cytosol map
  5. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*@Cytosol map → map ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*|​pho@Cytosol map
  6. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*|​pho@Cytosol map → map Actomyosin_contractility@default map
  7. ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*|​pho@Cytosol map → map ELC_MYOSIN_II*:​MYH*|​hm2:​RLC_MYOSIN_II*@Cytosol map
  8. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho:​WASP*:​WIPF1|​pho@INNATE_IMMUNE_CELL_Cytosol map
  9. ELC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map + RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map + MYH9|​hm2@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map
  10. ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*@INNATE_IMMUNE_CELL_Cytosol map → map ELC_MYOSIN_II*:​MYH9|​hm2:​RLC_MYOSIN_II*|​pho@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser:
  1. Actin cytoskeletal*@T_cell map → map Actin cytoskeletal*|​hm2@T_cell map
  2. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@T_cell map + WASP*|​Tyr291_pho|​active@T_cell map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​Tyr291_pho@T_cell map
  3. Actin cytoskeletal*@INNATE_IMMUNE_CELL_Cytosol map → map Actin cytoskeletal*|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  4. ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5@INNATE_IMMUNE_CELL_Cytosol map + WASP*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol map → map ACTR2:​ACTR3:​ARPC1*:​ARPC2:​ARPC3:​ARPC4:​ARPC5:​WASP*|​pho@INNATE_IMMUNE_CELL_Cytosol map