Identifiers
myosin heavy chain 9
HUGO:MYH9 hgnc_id:HGNC:7579 HGNC:7579 ENTREZ:4627 UNIPROT:P35579
myosin heavy chain 10
HUGO:MYH10 hgnc_id:HGNC:7568 HGNC:7568 ENTREZ:4628 UNIPROT:P35580
myosin heavy chain 14
HUGO:MYH14 hgnc_id:HGNC:23212 HGNC:23212 ENTREZ:79784 UNIPROT:Q7Z406
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
References
PMID:25712372
In mammals,
three genes (MYH9, MYH10, MYH14) encode for three
non-muscle myosin-2 isoforms referred to as -2A, -2B, and -
2C, respectively. Most cells simultaneously express two or
three non-muscle myosin-2 paralogs and their splice variants
in a strictly regulated manner. Each mammalian non-muscle
myosin-2 heavy chain associates with one ELC encoded by
one of two genes (MYL6, MYL6B) and with one RLC
encoded by either MYL9, MYL12A, or MYL12B.
MLCK and ROCK phosphorylares RLC
→ MYH*|hm2@Cytosol
+ RLC_MYOSIN_II*@Cytosol + MYH*|hm2@Cytosol → ELC_MYOSIN_II*:MYH*|hm2:RLC_MYOSIN_II*@Cytosol
→ ELC_MYOSIN_II*:MYH*|hm2:RLC_MYOSIN_II*|pho@Cytosol
→ Actomyosin_contractility@default
→ ELC_MYOSIN_II*:MYH*|hm2:RLC_MYOSIN_II*@Cytosol