Protein ACSF2
Identifiers
HUGO:ACSF2
Acyl-CoA synthetase family member 2
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death
/ FERROPTOSIS
References
PMID:27048822
PMID:26653790
PMID:26794443
ACSF2 and CS are required for mitochondrial fatty-acid metabolism in ferroptosis.
Knockdown of ACSF2 and CS inhibits erastin-induced ferroptosis
PMID:28645028
Modifications:
In compartment: Cytosol
- ACSF2@Cytosol
In compartment: Mitochondrial Matrix
- ACSF2@Mitochondrial Matrix
Participates in complexes:
Participates in reactions:
As Reactant or Product:
As Catalyser:- acetate@Mitochondrial Matrix
+ ATP@Mitochondrial Matrix
+ coenzyme A@Mitochondrial Matrix
→
acetyl-CoA@Mitochondrial Matrix
+ AMP@Mitochondrial Matrix
- acetate@Cytosol
+ ATP@Cytosol
+ coenzyme A@Cytosol
→
acetyl-CoA@Cytosol
+ AMP@Cytosol