RNA PTGER2 map

Identifiers
HUGO:PTGER2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
PMID:25916550
miR-149 targets IL-6 mRNA and is downregulated in GC CAFs
PGE2 receptor, PTGER2 and IL6, are potential targets of miR-149
PGE2 binds to EP2 and induces the hypermethylation and suppression of miR-149, reversing the downregulation of IL-6 and EP2 expression.
PMID:21209948
PGE2 can induce IL-6 expression in fibroblasts through EP2

Modifications:
In compartment: Cytosol
  1. rPTGER2@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. MIR149:​PTGER2@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. gPTGER2@Cytosol map → map rPTGER2@Cytosol map
  2. rPTGER2@Cytosol map → map PTGER2@Cytosol map
  3. rPTGER2@Cytosol map + arMIR149@Cytosol map → map MIR149:​PTGER2@Cytosol map
  4. MIR149:​PTGER2@Cytosol map → map degraded
As Catalyser: