Protein CDK7 map

Identifiers
cyclin-dependent kinase 7
HUGO:CDK7, HGNC:1778, ENTREZ:1022, UNIPROT:P50613

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
HMC:GENOME_INSTABILITY_AND_MUTATION
 Cell Cycle DNA Repair  map  / G1_CC_PHASE  map
 Cell Cycle DNA Repair  map  / S_CC_PHASE  map
 Cell Cycle DNA Repair  map  / NER  map

References
PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249, PMID:17386261
Role of CDK7/CycH (CAK) in the transcriptional regulation, a link between transcription and the cell cycle machinery
PMID:19667075, PMID:7533895
CDK7 participates in basal transcription by phosphorylating the carboxy-terminal domain of the largest subunit of RNA polymerase II

Modifications:
In compartment: Nucleus
  1. CDK7@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. CDK7:​CyclinH*:​MNAT1@Nucleus map
  2. CDK7:​CyclinH*:​MNAT1:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XPB*:​XPD*@Nucleus map
  3. CDK7:​CyclinH*:​MNAT1:​RPA2|​pho:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*@Nucleus map
  4. CDK7:​CyclinH*:​ERCC1:​MNAT1:​RPA2|​pho:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*:​XPF*:​XPG*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. CDK7:​CyclinH*:​MNAT1:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XPB*:​XPD*@Nucleus map + ce_s3289 + XAB2:​XPA|​S196_pho@Nucleus map → map CDK7:​CyclinH*:​MNAT1:​RPA2|​pho:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*@Nucleus map
  2. CDK7:​CyclinH*:​MNAT1:​RPA2|​pho:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*@Nucleus map + ERCC1@Nucleus map + XPF*@Nucleus map + XPG*@Nucleus map → map CDK7:​CyclinH*:​ERCC1:​MNAT1:​RPA2|​pho:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XAB2:​XPA|​S196_pho:​XPB*:​XPD*:​XPF*:​XPG*@Nucleus map
  3. XPB*@Nucleus map + XPD*@Nucleus map + TFIIH5*@Nucleus map + TFIIH1*@Nucleus map + TFIIH2*@Nucleus map + TFIIH3*@Nucleus map + TFIIH4*@Nucleus map + CDK7:​CyclinH*:​MNAT1@Nucleus map → map CDK7:​CyclinH*:​MNAT1:​TFIIH1*:​TFIIH2*:​TFIIH3*:​TFIIH4*:​TFIIH5*:​XPB*:​XPD*@Nucleus map
  4. CDK7@Nucleus map + CyclinH*@Nucleus map + MNAT1@Nucleus map → map CDK7:​CyclinH*:​MNAT1@Nucleus map
As Catalyser:
  1. gGG-NER_DNA_st2*@Nucleus map → map gTC-NER_GG-NER_DNA_st3*@Nucleus map
  2. gTC-NER_DNA_st2*@Nucleus map → map gTC-NER_GG-NER_DNA_st3*@Nucleus map
  3. gFanconi_DNA_st5*@Nucleus map → map gTC-NER_GG-NER_DNA_st4*@Nucleus map
  4. gTC-NER_GG-NER_DNA_st3*@Nucleus map → map gTC-NER_GG-NER_DNA_st4*@Nucleus map + Modified 24-32 nucleotides fragment@Nucleus map
  5. CDK1|​Y14/15_pho:​CyclinB1*@Nucleus map → map CDK1|​Y14/15_pho|​T161_pho:​CyclinB1*@Nucleus map
  6. CDK2|​Y14/15_pho:​CyclinE*@Nucleus map → map CDK2|​T160_pho|​Y14/15_pho:​CyclinE*@Nucleus map
  7. CDK4_6*|​Y14_pho:​CyclinD*@Nucleus map → map CDK4_6*|​T172_pho|​Y14_pho:​CyclinD*@Nucleus map
  8. CDK2|​Y14/15_pho:​CyclinA1*@Nucleus map → map CDK2|​T160_pho|​Y14/15_pho:​CyclinA1*@Nucleus map
  9. CDK1|​Y14/15_pho:​CyclinA1*@Nucleus map → map (CDK1|​Y14/15_pho|​T161_pho:​CyclinA1*)|​active@Nucleus map