Protein ERCC1
Identifiers
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
HUGO:ERCC1, HGNC:3433, ENTREZ:2067, UNIPROT:P07992
Maps_Modules
HMC:GENOME_INSTABILITY_AND_MUTATION
Cell Cycle DNA Repair
/ NER
Cell Cycle DNA Repair
/ A_NHEJ
Cell Cycle DNA Repair
/ FANCONI
Cell Cycle DNA Repair
/ SSA
References
PMID:22373527, PMID:23085398, PMID:22824526, PMID:22373527, PMID:22257761
PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153:G, PMID:11900249
For Fanconi pathway
PMID:19686080
For SSA pathway
PMID:19473888, PMID:12947387, PMID:19596235, PMID:19595721, PMID:19596236
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743, PMID:24050180, PMID:22743550
Modifications:
In compartment: Nucleus
- ERCC1@Nucleus
Participates in complexes:
In compartment: Nucleus
- ERCC1:XPF*@Nucleus
- ERCC1:SLX4*:XPF*@Nucleus
- ERCC1:MLH1:PMS2:XPF*@Nucleus
- CDK7:CyclinH*:ERCC1:MNAT1:RPA2|pho:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*:XPF*:XPG*@Nucleus
Participates in reactions:
As Reactant or Product:- ERCC1@Nucleus
+ XPF*@Nucleus
→
ERCC1:XPF*@Nucleus
- CDK7:CyclinH*:MNAT1:RPA2|pho:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*@Nucleus
+ ERCC1@Nucleus
+ XPF*@Nucleus
+ XPG*@Nucleus
→
CDK7:CyclinH*:ERCC1:MNAT1:RPA2|pho:TFIIH1*:TFIIH2*:TFIIH3*:TFIIH4*:TFIIH5*:XAB2:XPA|S196_pho:XPB*:XPD*:XPF*:XPG*@Nucleus
- MLH1:PMS2@Nucleus
+ ERCC1:XPF*@Nucleus
→
ERCC1:MLH1:PMS2:XPF*@Nucleus
- SLX4*@Nucleus
+ ERCC1:XPF*@Nucleus
→
ERCC1:SLX4*:XPF*@Nucleus
As Catalyser:- gA_NHEJ_DNA_st3*@Nucleus
→
gA_NHEJ_DNA_st4*@Nucleus
- gFanconi_DNA_st3*@Nucleus
→
gFanconi_DNA_st4*@Nucleus
- gFanconi_DNA_st5*@Nucleus
→
gTC-NER_GG-NER_DNA_st4*@Nucleus
- gSSA_DNA_st4*@Nucleus
→
gSSA_DNA_st5*@Nucleus
- gTC-NER_GG-NER_DNA_st3*@Nucleus
→
gTC-NER_GG-NER_DNA_st4*@Nucleus
+ Modified 24-32 nucleotides fragment@Nucleus