Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 

References
PMID:9865696
SARA interacts directly with Smad2 and Smad3
PMID:11792802
SARA is a cytoplasmic protein that specifically interacts withe no-activated Smad2 and the receptor complex
SARA thus forms the bridge between the receptor and Smad2 and assisting in the specific phosphorylation of Smad2 by the TGFBR1
The stable interaction of SARA with non-phosphorylated Smad2 also inhibits nuclear import of Smad2
PMID:10934479
The nuclear import function of Smad2 is masked by SARA and unmasked by TGFB- dependent phosphorylation