Identifiers
Yes associated protein 1
HUGO:YAP1 hgnc_id:HGNC:16262 HGNC:16262 ENTREZ:10413 UNIPROT:P46937
Yes-associated protein 1, 65kDa
HUGO:YAP1, HGNC:16262, ENTREZ:10413, UNIPROT:P46937
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / MOTILITY
Cancer Associated Fibroblasts / CORE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G2_M_CHECKPOINT
References
PMID:23708000
YAP is activated in cancer-associated fibroblasts in human disease
YAP is required for cancer associated fibroblast function
6 out of the 14 genes with elevated mRNA levels in CAFs were found to be consistently transcriptionally regulated by YAP (AMOTL2, ANKRD1, ANLN, CTGF, DIAPH3, SDPR).
ANLN, DIAPH3 and FLNA were required for CAFs to both remodel the ECM and promote invasion
PMID:25502501
yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis.
Knockdown of YAP and TAZ together in vitro attenuates key fibroblast functions, including matrix synthesis, contraction, and proliferation, and does so exclusively on pathologically stiff matrices. Profibrotic effects of YAP and TAZ operate, in part, through their transcriptional target plasminogen activator inhibitor-1 (SERPINE1), which is regulated by matrix stiffness independent of transforming growth factor-?? signaling.
PMID:26711338
Cdc42EP3 Is Required for Mechano-transduction and YAP activation
PMID:7782338, PMID:12807903, PMID:18280240, PMID:18617895, PMID:21666501
References
ce_re58:( Cell Cycle DNA Repair ) PMID:19788416
References
ce_re58:( Cell Cycle DNA Repair ) PMID:19788416