Complex WWTR1:YAP1 map
Complex composition:

  1. YAP1 map
  2. WWTR1 map

WWTR1:​YAP1@Cytosol

Identifiers
NAME:WWTR1:YAP1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map

References
PMID:25502501
yes-associated protein (YAP) (homolog of drosophila Yki) and transcriptional coactivator with PDZ-binding motif (TAZ) (also known as Wwtr1), transcriptional effectors of the Hippo pathway, as key matrix stiffness-regulated coordinators of fibroblast activation and matrix synthesis.
Knockdown of YAP and TAZ together in vitro attenuates key fibroblast functions, including matrix synthesis, contraction, and proliferation, and does so exclusively on pathologically stiff matrices. Profibrotic effects of YAP and TAZ operate, in part, through their transcriptional target plasminogen activator inhibitor-1 (SERPINE1), which is regulated by matrix stiffness independent of transforming growth factor-?? signaling.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. WWTR1:​YAP1@Cytosol map
Participates in reactions:
As Reactant or Product:
    As Catalyser:
    1. gSERPINE1@Cytosol map → map rSERPINE1@Cytosol map