Identifiers
WASP_N-WASP*
Wiskott-Aldrich syndrome
IMD2, THC, "thrombocytopenia 1 (X-linked)", "Wiskott-Aldrich syndrome (eczema-thrombocytopenia)"
HUGO:WAS HGNC:12731 ENTREZ:7454 UNIPROT:P42768
Wiskott-Aldrich syndrome-like
HUGO:WASL HGNC:12735 ENTREZ:8976 UNIPROT:O00401
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
References
em_emtc_emtc_re858( EMT Senescence ):
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:10940259
CDC42 initiates WASP/Arp2_3 nucleation of actin.
PMID:15713627
Spatially distinct binding of Cdc42 to PAK1 and N-WASP
em_emtc_emtc_re791( EMT Senescence ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.