Protein PAK4 map

Identifiers
p21 protein (Cdc42/Rac)-activated kinase 4
"p21(CDKN1A)-activated kinase 4"
HUGO:PAK4 HGNC:16059 ENTREZ:10298 UNIPROT:O96013

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

PAK4@Cytosol

References
em_emtc_emtc_re843( EMT Senescence  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.

Modifications:
In compartment: Cytosol
  1. PAK4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. PAK4@Cytosol map → map PAK4@Cytosol map
    2. PAK4@Cytosol map → map JNK pathway@Cytosol map
    As Catalyser:
    1. LIMK1@Cytosol map → map LIMK1|​pho|​active@Nucleus map