Reaction known_transition_omitted em_emtc_emtc_re472 map

LIMK1@Cytosol map → LIMK1|​pho|​active@Nucleus map

Reaction regulators:
Catalysis
  1. PAK1@Cytosol map
  2. CDC42BPA@Cytosol map
  3. PAK4@Cytosol map
  4. ROCK*|​active|​open@Cytosol map


References
PMID:22154077, PMID:17522712
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:11018042
LIMK1 is regulated by Pak1,