Identifiers
Fas apoptotic inhibitory molecule
HUGO:FAIM HGNC:18703 ENTREZ:55179 UNIPROT:Q9NVQ4
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / FAS_RESPONSE
References
PMID:17942717
The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis
FAIM(L) can bind to Fas receptor and prevent the activation of the initiator caspase-8 induced by Fas
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / FAS_RESPONSE
References
rc_re1674( Regulated Cell Death ):
Apoptosis complex led by FAS ligation
PMID:12702723
PMID:9184224
PMID:23069999
PMID:16498403
caspase-8 formed triple complex with TRAF2 and FLASH. Taken together, these results suggest that endogenous caspase-8 mediates TNF-alpha-induced activation of NF-kappaB via FLASH