Protein trIL1B map

Identifiers
HUGO:IL1B

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / INFLAMMATORY_SIGNALING_PATHWAYS  map

References
CASCADE:IL1
PMID:20138012
Tumor-enhancing activity of skin CAFs is NF-??B dependent and activatable by IL-1??
PMID:19747910
Through paracrine signaling molecules, TGF-beta and IL-1beta, cancer cells activate stromal fibroblasts and induce the expression of fibroblast activation protein (FAP). FAP, in turn, affects the proliferation, invasion and migration of the cancer cells. We report that TGF-beta and IL-1beta are important factors in inducing differentiation of myofibroblasts and expression of functional markers, notably alpha-SMA.
PMID:9242465
IL1B, FGF2, FGF1, FGF4, PDGF induce HGF expression and production in fibroblasts

Modifications:
In compartment: Cytosol
  1. trIL1B@Cytosol map
In compartment: default
  1. trIL1B@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. IL1B@Cytosol map → map trIL1B@Cytosol map
    2. trIL1B@Cytosol map → map trIL1B@default map
    As Catalyser:
    1. IL1R1:​IL1RAP@Cytosol map + MYD88@Cytosol map + IRAK4@Cytosol map → map IL1R1:​IL1RAP:​IRAK4:​MYD88@Cytosol map
    2. gHGF@Cytosol map → map rHGF@Cytosol map