Protein HMGB1 map

Identifiers
HUGO:HMGB1

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSTIMULATORY_CYTOKINE_PATHWAYS

References
PMID:19197071, PMID:21372296
HMGB1 is secreted by M1 activated macrophages and macrophages expressed TLR4.
PMID:17704786
HMGB1 is secreted by dying tumor cells.
PMID:25164013
HMGB1 activates MDSCs via the NF-??B pathway It increases MDSC-mediated production of IL-10, enhanced crosstalk between MDSCs and macrophages, and facilitated the ability of MDSCs to downregulate expression of the T-cell homing receptor L-selectin.

HMGB1@default

Identifiers

Maps_Modules

References

HMGB1@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. HMGB1@Cytosol map
In compartment: default
  1. HMGB1@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. HMGB1@default map → map Tumor invasion@Membrane map
    2. HMGB1@default map → map Angiogenesis@default map
    3. HMGB1@Cytosol map → map HMGB1@default map
    As Catalyser:
    1. rMHC class II*@Cytosol map → map MHC class II*@Cytosol map
    2. TLR2/4*@Membrane map + LY96@Membrane map + TIRAP@Membrane map + MYD88@Membrane map + CD14@Membrane map → map CD14:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
    3. rTLR2@Cytosol map → map TLR2@Membrane map
    4. rTLR4@Cytosol map → map TLR4@Membrane map
    5. rIL1RN@Cytosol map → map IL1RN@Cytosol map
    6. rCCL4@Cytosol map → map CCL4@Cytosol map