Simple molecule lactic acid
lactic acid @default
PMID:25043024
Lactic acid is sufficient to induce Vegf and Arg1 via HIF1??.
Lactic acid, probably via HIF1A polarizes macrophages to an M2-Iike state that is critical for tumour growth
Modifications:
In compartment: default
- lactic acid @default
Participates in complexes:
Participates in reactions:
As Reactant or Product:- Hypoxia@default
→
lactic acid @default
As Catalyser:- HIF1A@Cytosol
→
HIF1A@Cytosol