Protein ARG1 map

Identifiers
HUGO:ARG1

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:NO_ROS_PRODUCTION

References
PMID:12193690, PMID:17476345
A hallmark of ???alternative activation??? (M2) of macrophages
is high arginase activity, which competes with inducible NO
synthase for??L-arginine, the common substrate
of both enzymes. ARG1 activation has been regarded as one of
the most specific markers of M2 macrophages.
PMID: 20644162
Human MDSC express AGR1
PMID:12496409
Arg1 is up-regulated in MDSC by IL-4.
Arg1 increases superoxide production in myeloid cells through a pathway that likely utilizes the reductase domain of inducible NO synthase (iNOS), and that superoxide is required for Arg1-dependent suppression of T cell function.

References_end
ARG1@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. ARG1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rARG1@Cytosol map → map ARG1@Cytosol map
    As Catalyser:
    1. L-arginine@Cytosol map → map Urea@Cytosol map + L-ornitine@Cytosol map
    2. O_sub_2_endsub_@Cytosol map → map O_sub_2_endsub__super_-_endsuper_@Cytosol map