Protein IRF8 map
HUGO:IRF8
MODEULE:MACROPHAGE
MODEULE:MDSC
MODULE:CORE_SIGNALING_PATHWAYS
PMID:24091328
(a) Irf8-deficient mice generated myeloid populations highly homologous to tumor-induced MDSCs with respect to phenotype, function, and gene expression profiles; (b) IRF-8 overexpression in mice attenuated MDSC accumulation and enhanced immunotherapeutic efficacy; (c) the MDSC-inducing factors G-CSF and GM-CSF facilitated IRF-8 downregulation via STAT3- and STAT5-dependent pathways; and (d) IRF-8 levels in MDSCs of breast cancer patients declined with increasing MDSC frequency, implicating IRF-8 as a negative regulator in human MDSC biology.
IRF-8 levels are depressed in MDSCs of breast cancer patients.
PMID:12417340
IRF-8/ICSBP and IRF-1 cooperatively stimulate mouse IL-12 p40 promoter activity in macrophages.
PMID:16597464
IRF-8 and IRF-1 are the target genes in activated macrophages.
The expression levels of CXCL16, H28, IL-17R, LIF, MAP4K4, MMP9, MYC, PCDH7, PML, and SOCS7 were signi???cantly increased in macrophages
extracted form WT mice (black columns) following activation
for 4 h with IFNG and LPS. However, no changes in the expression of these genes were observed in cells extracted from IRF-8,
as well as from IRF-1 null mice.
Modifications:
In compartment: Cytosol
  1. IRF8@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rIRF8@Cytosol map → map IRF8@Cytosol map
    As Catalyser:
    1. gMYC@Cytosol map → map rMYC@Cytosol map
    2. gIL12p40*@Cytosol map → map rIL12p40*@Cytosol map
    3. gMMP9@Cytosol map → map rMMP9@Cytosol map