Protein PTGER4
MODULE:MDSC
MODULE:RECRUITMENT_OF_IMMUNE_CELLS
PMID:22025564
PGE2 induces expression of CXCR4 in MDSC
Inhibition of COX2 or the PGE2 receptors EP2/EP4 in MDSCs suppressed expression of CXCR4 and MDSC responsiveness to CXCL12 or ovarian cancer ascites.
PMID:16186186
PGE2 receptor E-prostanoid 4 expressed in MSCs induced arginase I.

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Modifications:
In compartment: Membrane

1. PTGER4@Membrane

Participates in complexes:
In compartment: Membrane

1. PGE2:​PTGER4@Membrane

Participates in reactions:
As Reactant or Product:

1. PGE2@default + PTGER4@Membrane → PGE2:​PTGER4@Membrane

As Catalyser:

1. gARG1@Cytosol → rARG1@Cytosol
2. gCXCR4@Cytosol → rCXCR4@Cytosol