Simple molecule PGE2 map
PGE2@Cytosol
PMID:22025564
COX2 catalyses synthesis of PGE2 in MDSC.
PGE2@default
PMID:22025564
COX2 catalyses synthesis of PGE2 in MDSC.
PGE2 induces expression of CXCR4 in MDSC
Inhibition of COX2 or the PGE2 receptors EP2/EP4 in MDSCs suppressed expression of CXCR4 and MDSC responsiveness to CXCL12 or ovarian cancer ascites.
Modifications:
In compartment: Cytosol
  1. PGE2@Cytosol map
In compartment: default
  1. PGE2@default map
Participates in complexes:
In compartment: Membrane
  1. PGE2:​PTGER2@Membrane map
  2. PGE2:​PTGER4@Membrane map
Participates in reactions:
As Reactant or Product:
  1. Arachidonic acid@Cytosol map → map PGE2@Cytosol map
  2. PGE2@Cytosol map → map PGE2@default map
  3. PGE2@default map + PTGER2@Membrane map → map PGE2:​PTGER2@Membrane map
  4. PGE2@default map + PTGER4@Membrane map → map PGE2:​PTGER4@Membrane map
As Catalyser:
  1. gARG1@Cytosol map → map rARG1@Cytosol map
  2. gCXCR4@Cytosol map → map rCXCR4@Cytosol map