Identifiers
latency-associated protein*
HUGO:TGFB1, HGNC:11766, ENTREZ:7040, UNIPROT:P01137, GENECARDS:GC19M041837
HUGO:TGFB3, HGNC:11769, ENTREZ:7043, UNIPROT:P10600, GENECARDS:GC14M076424
HUGO:TGFB2, HGNC:11768, ENTREZ:7042, UNIPROT:P61812, GENECARDS:GC01P218519

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / ECM 

References
PMID:21900405
LAP: Latency-associated peptiden encoded by TGFB gene
There are 3 LAPs (1, 2, 3) corresponding to 3 TGFB (1, 2, 3)
LAP1 contains the RGD motif which is the binding site for integrins aVb1, aVb3, aVb5, aVb6, aVb8, a8b1
PMID:19920116
LAP is known to bind to ITG heterodimers and activate TGFB.
LAP and TGFB were also prominently expressed at the basal surface of endometrial epitheliaModules_bigin:

References
em_emtc_emtc_re226( EMT Senescence  ):
PMID:20519943
PMID:17934056
PMID:16474430
PMID:14557817
PMID:21900405
TGFB inhibits proliferation
TGFB overproduction causes fibrosis.
Each TGFB gene encodes a preproprotein sequence consisting of a signal peptide, a propeptide (LAP) and the mature TGFB
After translocation into the endoplamic reticulum, TGFB proprotein monomers form homomdimers liked by disulfide bonds, forming pro-TGFB
In the Golgi, the prodomains undergo glycosylation.
Also in the Golgi, FURIN hydolyzes the leavage site from LAP, creating TGFB and LAP-derived homodimers
The 2 homodimers remain noncovalently associated and are secreted.
The LAP-derived homodimer prevents TGFB from binding TGFB receptors.

1. Latency-associated protein*|​hm2@Extracellular space

1. Latency-associated protein*:​TGFB1@Extracellular space
2. LTBP1:​Latency-associated protein*|​hm2@Extracellular space
3. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
4. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
5. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space
6. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
7. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
8. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space

1. Latency-associated protein*|​hm2@Extracellular space + TGFB1|​hm2|​active@Extracellular space → Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
2. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space + LTBP1@Extracellular space → LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
3. Integrin A8B1_AVB1_AVB5_AVB6_AVB8*@Extracellular space + LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space → Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
4. Actin cytoskeletal*@Cytosol + Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space → Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
5. Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space → Latency-associated protein*|​hm2@Extracellular space + TGFB1|​hm2|​active@Extracellular space
6. LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space → TGFB1|​hm2|​active@Extracellular space + LTBP1:​Latency-associated protein*|​hm2@Extracellular space
7. Latency-associated protein*:​TGFB1@Extracellular space → Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space
8. Actin cytoskeletal*:​Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2:​TGFB1|​hm2@Extracellular space → Integrin A8B1_AVB1_AVB5_AVB6_AVB8*:​LTBP1:​Latency-associated protein*|​hm2@Extracellular space + TGFB1|​hm2|​active@Extracellular space