Protein AREG map

Identifiers
amphiregulin
HUGO:AREG hgnc_id:HGNC:651 HGNC:651 ENTREZ:374 UNIPROT:P15514
HUGO:AREG

References
MODULE:GROWTH_FACTORS_PRODUCTION
PMID:23010081
Celecoxib (specific COX-2 inhibitor)increases EGF signaling in colon tumor associated fibroblasts, modulating EGFR expression and degradation
and increase colon TAFs proliferation in the presence of EGF.
Also it induces neo-expression and release of Amphiregulin (AREG), a well known EGFR agonist;
EGF signaling induces AREG release.
PMID:20430953

Modifications:
In compartment: Cytosol
  1. AREG@Cytosol map
In compartment: Membrane
  1. AREG@Membrane map
In compartment: default
  1. AREG@default map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rAREG@Cytosol map → map AREG@Cytosol map
    2. AREG@Cytosol map → map AREG@default map
    As Catalyser:
    1. EGFR@Cytosol map + ERBB*@Cytosol map → map EGFR:​ERBB*@Cytosol map
    2. EGFR@Membrane map + ERBB*@Membrane map → map EGFR:​ERBB*@Membrane map