Protein CDC42EP3 map

Identifiers
HUGO:CDC42EP3
CDC42 effector protein (Rho GTPase binding) 3
HUGO:CDC42EP3 HGNC:16943 ENTREZ:10602 UNIPROT:Q9UKI2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:27248291
Cdc42 regulates Cdc42EP3 function in cancer-associated ???broblasts
Cdc42-binding defective mutant of Cdc42EP3 (Cdc42EP3-IS)
could not interact with actin. Inhibiting Cdc42 function by transient expression of the dominant negative Cdc42-N17
protein resulted in a loss of ???lamentous Cdc42EP3 structures and reduced F-actin stress ???bers and ???lamentous
SEPT2
PMID:26711338
Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities of CAFs. Cdc42EP3 functions by coordinating the actin and septin networks. Furthermore, depletion of SEPT2 has similar effects to those of loss of Cdc42EP3, indicating a role for the septin network in the tumor stroma.
Cdc42EP3 Is Required for Mechano-transduction and YAP Activation

Modifications:
In compartment: Cytosol
  1. CDC42EP3@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. CDC42EP3@Cytosol map → map Angiogenesis@default map
    2. CDC42EP3@Cytosol map → map TUMOR_GROWTH@default map
    3. CDC42EP3@Cytosol map → map CDC42EP3@Cytosol map
    4. CDC42EP*@Cytosol map → map CDC42EP3@Cytosol map
    As Catalyser:
    1. Actin cytoskeletal*@Cytosol map → map Actin cytoskeletal*|​hm2|​active@Cytosol map
    2. SEPTINS*@Cytosol map → map Septins_polymerization@Cytosol map
    3. YAP1@Cytosol map → map YAP1@Cytosol map