Protein SEPTINS* map

Identifiers
HUGO:SEPT1 HUGO:SEPT2 HUGO:SEPT3 HUGO:SEPT4 HUGO:SEPT5 HUGO:SEPT6 HUGO:SEPT7 HUGO:SEPT8 HUGO:SEPT9 HUGO:SEPT10 HUGO:SEPT11 HUGO:SEPT12 HUGO:SEPT14

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / MOTILITY  map

References
PMID:22314400
Septins: the fourth component of the cytoskeleton (REW)
PMID:26711338
Cdc42EP3/BORG2 is required for the matrix remodeling, invasion, angiogenesis, and tumor-growth-promoting abilities of CAFs. Cdc42EP3 functions by coordinating the actin and septin networks. Furthermore, depletion of SEPT2 has similar effects to those of loss of Cdc42EP3, indicating a role for the septin network in the tumor stroma.
Altered Septin Networks Are a Feature of CAFs
EPT2 and SEPT7 formed more extensive networks in CAFs
AFs Require Cdc42EP3 and SEPT2 to Promote Angiogenesis and Tumor Growth

Modifications:
In compartment: Cytosol
  1. SEPTINS*@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. SEPTINS*@Cytosol map → map Septins_polymerization@Cytosol map
    2. SEPTINS*@Cytosol map → map Angiogenesis@default map
    3. SEPTINS*@Cytosol map → map TUMOR_GROWTH@default map
    As Catalyser: