Protein S100A4 map

Identifiers
S100 calcium binding protein A4
HUGO:S100A4 hgnc_id:HGNC:10494 HGNC:10494 ENTREZ:6275 UNIPROT:P26447

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / FIBROBLAST_ACTIVATION_MARKERS  map

References
CASCADE:TGFB
PMID:23784029
TGFB upregulates FSP1 (S100A4) expression via Smad2 and smad3
PMID:23034983
TGFB upregulates gene expression of CAF markers ,??FSP1 (S100A4), and??TNC. (provably via SMAD3), and gene expression of CCL5, SDF1, BMP4, IL6, CXCL7, IL6R,IL6ST,CXCL5
PMID:7615639
Identification and characterization of a fibroblast marker: FSP1.
PMID:20103644
Tumor infiltration of T lymphocytes is mediated in part through CAF-secreted S100A4/FSP-1
Moreover, S100A4 not only attracted T lymphocytes but also activated them, which was manifested by cytokine production: S100A4-stimulated T cells produced increased levels of distinct cytokines and growth factors including CCL5/RANTES, CXCL16, IL-4, G-CSF and MIP

Modifications:
In compartment: Cytosol
  1. S100A4@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. rS100A4@Cytosol map → map S100A4@Cytosol map
    2. S100A4@Cytosol map → map FIBROBLAST_MARKERS@default map
    3. S100A4@Cytosol map → map IMMUNE_SYSTEME_MODULATION@default map
    As Catalyser: