SURF1

Protein SURF1

Identifiers
surfeit 1
HUGO:SURF1 HGNC:11474 ENTREZ:6834 UNIPROT:Q15526

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / MITOCHONDRIAL_GENES
Regulated Cell Death / MITOCHONDRIAL_METABOLISM
Regulated Cell Death / OXIDATIVE_PHOSPHOYLATION_AND_TCA_CYCLE

References
PMID:10556303
in simian COS7 cells,transiently expressed Flag-tagged human SURF1 resides at the inner membrane of mitochondria

SURF1@Mitochondrial inner membrane

References
rc_re93( Regulated Cell Death ):
PMID:15119951
SURF1 mutations are associated with Leigh syndrome (cytochrome oxidase deficiency)
PMID:11389896
SURF1 Homolog of Yeast (Shy) is necessary for COX assembly and stability
PMID:19625251
Paroccocus denitrificans SURF1 homologs were proposed to promote heme a insertion into COX subunit 1

Modifications:
In compartment: Mitochondrial inner membrane

SURF1@Mitochondrial inner membrane

Participates in complexes:

Participates in reactions:
As Reactant or Product:

rSURF1@Nucleus → SURF1@Mitochondrial inner membrane

As Catalyser:

degraded + MT-CO1@Mitochondrial inner membrane + COX5A@Mitochondrial inner membrane + COX6A*@Mitochondrial inner membrane + COX5B@Mitochondrial inner membrane + COX7A*@Mitochondrial inner membrane + heme a@Mitochondrial intermembrane space + MT-CO3@Mitochondrial inner membrane + Cu2+:MT-CO2@Mitochondrial inner membrane → COX4I1:COX5A:COX5B:COX6A*:COX6B*:COX6C:COX7A*:COX7B*:COX7C:COX8*:Cu2+:MT-CO1:MT-CO2:MT-CO3:heme a@Mitochondrial inner membrane