Identifiers
WNK lysine deficient protein kinase 4
HUGO:WNK4, HGNC:14544, ENTREZ:65266, UNIPROT:Q96J92, GENECARDS:GC17P040932 ??

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CELL_CELL_ADHESIONS 
 EMT Senescence   / TIGHT_JUNCTIONS 

References
PMID:15070779
WNK4 binds and phosphorylates claudins 1???4.
Claudins 1???4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability

References
em_emtc_emtc_re483( EMT Senescence  ):
PMID:15070779
WNK4 binds and phosphorylates claudins 1???4.
Claudins 1???4 are known to be involved in the regulation of paracellular ion permeability.
The increases in phosphorylation of claudins were greater in cells expressing the mutant WNK4 than in cells expressing wild-type protein.
Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.
So the phosphorylation of Claudins 1-4 by WNK4 involves in the regulation of paracellular ion permeability

1. WNK4@Cytosol

1. Claudin1_2_3_4*@Cytosol + ATP@Cytosol → Claudin1_2_3_4*|​pho@Cytosol + ADP@Cytosol