Identifiers
RhoB_GDIs*
Rho GDP dissociation inhibitor (GDI) alpha
HUGO:ARHGDIA, HGNC:678, ENTREZ:396, GENECARDS:GC17M079825, UNIPROT:P52565
Rho GDP dissociation inhibitor (GDI) gamma
HUGO:ARHGDIG, HGNC:680, ENTREZ:398, GENECARDS:GC16P000318, UNIPROT:Q99819
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / CYTOSKELETON_POLARITY
References
The most known RhoB_GDIs are ARHGDIA and ARHGDIG.
They bind to RhoB and suppress its activation.
PMID:11368848
PMID:8939998
RhoGDI-3 (ARHGDIG) interacts specifically with GDP- and GTP-bound forms of post-translationally processed RhoB and RhoG proteins.
No interaction is found with RhoA, RhoC, or Rac1 proteins.
RhoGDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes.
References
em_emtc_emtc_re727( EMT Senescence ):
PMID:9857026
GEF-H1 is so-called ARHGEF2
GEFH1, which associates with tubulin in a manner dependent on a Zn-finger motif, is a regulator of the Rho family
GEFH1 is known to activate Rho A, B, C, and Rac1 but is inactive toward Cdc42, TC10, or Ras.
GEFH1 may have a direct role in activation of Rac and/or Rho and in bringing the activated GTPase to specific target sites such as microtubules.
PMID:16917499
The activation of GEFH1- RhoB through the TRIF-dependent pathway of LPS in DC might be a critical target for controlling the activation of CD4+ T cells.
PMID:12221096
XPLN (so-called ARHGEF3) is a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
PMID:16112081
In vitro, GrinchGEF (ARHGEF10L) induced the GDP/ GTP exchange at RhoA, but not at Rac1 or Cdc42.
In intact cells, GrinchGEF induced specifically Rho activation and enhanced RhoA,B,C-specific downstream effect.
GrinchGEF, similar to its relative p164-RhoGEF (ARHGEF17), is a Rho-specific GEF.
Although RhoA, B, and C have different cellular functions, and some regulators and effectors show preferential interaction with these Rho isoforms, GrinchGEF apparently does not distinguish between RhoA,B,C and similarly activates these Rho proteins
PMID:9822605
Phosphorylated Vav-2 was found to be active on RhoA, RhoB and the more distantly related RhoG protein
em_emtc_emtc_re728( EMT Senescence ):
The most known RhoB_GDIs are ARHGDIA and ARHGDIG.
They bind to RhoB and suppress its activation.
PMID:11368848
em_emtc_emtc_re729( EMT Senescence ):
PMID:8939998
RhoGDI-3 (ARHGDIG) interacts specifically with GDP- and GTP-bound forms of post-translationally processed RhoB and RhoG proteins.
No interaction is found with RhoA, RhoC, or Rac1 proteins.
RhoGDI-3 is able to inhibit GDP/GTP exchange of RhoB and to release GDP-bound but not GTP-bound RhoB from cell membranes.
em_emtc_emtc_s2942