Protein ARHGDIA map

Identifiers
Rho GDP dissociation inhibitor (GDI) alpha
HUGO:ARHGDIA, HGNC:678, ENTREZ:396, GENECARDS:GC17M079825, UNIPROT:P52565

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CYTOSKELETON_POLARITY  map

References
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.

ARHGDIA@Cytosol

References
em_emtc_emtc_re681( EMT Senescence  map ):
PMID:9113980
RhoGDI (so-called ARHGDIA) and GDIG4 (so-called ARHGDIB) are two known GDIs for the Rho-subfamily of GTPases.
ARHGDIG is about 50 percent identical to ARHGDIA and ARHGDIB. ARHGFIG binds to CDC42 and RhoA with less affinity compared with ARHGDIA and does not bind with Rac1, Rac2, or Ras.
ARHGDIG functions as a GDI for CDC42 but with about 20 times less efficiency than ARHGDIA.
PMID:9490022
ARHGDIA,B,G are CDC42_GDIs
em_emtc_emtc_re728( EMT Senescence  map ):
The most known RhoB_GDIs are ARHGDIA and ARHGDIG.
They bind to RhoB and suppress its activation.
PMID:11368848

Modifications:
In compartment: Cytosol
  1. ARHGDIA@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. Plakoglobin binding partners*@Cytosol map → map ARHGDIA@Cytosol map
    2. RhoA_and_CDC42_GDIs*@Cytosol map → map ARHGDIA@Cytosol map
    3. RhoB_GDIs*@Cytosol map → map ARHGDIA@Cytosol map
    4. Rac1_GDIs*@Cytosol map → map ARHGDIA@Cytosol map
    As Catalyser: