Protein HEY1_2* map

Identifiers
hes-related family bHLH transcription factor with YRPW motif 1
HUGO:HEY1, HGNC:4880, ENTREZ:23462, UNIPROT:Q9Y5J3, GENECARDS:GC08M080676
hes-related family bHLH transcription factor with YRPW motif 2
HUGO:HEY2, HGNC:4881, ENTREZ:23493, UNIPROT:Q9UBP5, GENECARDS:GC06P126068

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map

References
PMID:18497317
Notch1, Hey1, and Hey2 physically interact with and repress the function of the transcription factor RUNX2.

HEY1_2*@Nucleus

References
em_emtc_emtc_re1371( EMT Senescence  map ):
PMID:18497317
Notch1, Hey1, and Hey2 physically interact with and repress the function of the transcription factor RUNX2.
em_emtc_emtc_re1381( EMT Senescence  map ):
PMID:16567498
PMID:17587822
EZH1 and EZH2 are targets of HEYs-mediated transcriptional repression.
This finding suggests that TGFB-activated EMT could be controlled through structural histone modification.

Modifications:
In compartment: Nucleus
  1. HEY1_2*@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. HEY1_2*:​RUNX2@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. HEY1_2*@Nucleus map → map HEY1@Nucleus map
  2. HEY1_2*@Nucleus map → map HEY2@Nucleus map
  3. HEY1_2*@Nucleus map + RUNX2@Nucleus map → map HEY1_2*:​RUNX2@Nucleus map
As Catalyser:
  1. gEZH1@Nucleus map → map rEZH1@Nucleus map
  2. gEZH2@Nucleus map → map rEZH2@Nucleus map