Identifiers
Fibronectin partners
NAME:a5b1*
ITGA5/ITGB1
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
HUGO:ITGA5, HGNC:6141, ENTREZ:3678, UNIPROT:P08648, GENECARDS:GC12M054789
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1, HGNC:6153, ENTREZ:3688, UNIPROT:P05556, GENECARDS:GC10M033189
NAME:aVb3*
ITGAV/ITGB3
integrin, alpha V
"antigen identified by monoclonal antibody L230", "integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)", MSK8, "vitronectin receptor", VNRA, VTNR
HUGO:ITGAV HGNC:6150 ENTREZ:3685 UNIPROT:P06756 GENECARDS:GC02P187418
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GP3A
HUGO:ITGB3 HGNC:6156 ENTREZ:3690 UNIPROT:P05106 GENECARDS:GC17P045331
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
GP2B, "integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B)"
HUGO:ITGA2B HGNC:6138 ENTREZ:3674 UNIPROT:P08514
NAME:a2b1*
ITGA2/ITGB1
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
CD49B
HUGO:ITGA2 HGNC:6137 ENTREZ:3673 UNIPROT:P17301
NAME:a10b1*
ITGA10/ITGB1
integrin, alpha 10
HUGO:ITGA10 HGNC:6135 ENTREZ:8515 UNIPROT:O75578
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
EMT Senescence / CELL_MATRIX_ADHESIONS
References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:19487819
During gastrulation, type 1 EMT is associated with de novo expression of a5b1, which is a receptor for fibronectin.
Type 2 EMT in experimental kidney fibrosis is associated with increased a5 integrin expression.
+ Fibronectin partners*@Extracellular space → Fibronectin partners*:Fibronectin*@Extracellular space
→ Cell-matrix adhesions@Extracellular space
→ a5b1*_aVb3*@Extracellular space
→ em_emtc_emtc_s3290
→ em_emtc_emtc_s3328
→ em_emtc_emtc_s3291