Identifiers
a2b1*_a3b1*
NAME:a2b1*
ITGA2/ITGB1
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
CD49B
HUGO:ITGA2 HGNC:6137 ENTREZ:3673 UNIPROT:P17301
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
HUGO:ITGB1, HGNC:6153, ENTREZ:3688, UNIPROT:P05556, GENECARDS:GC10M033189
NAME:a3b1*
ITGA3/ITGB1
integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
"antigen identified by monoclonal antibody J143", MSK18
HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
EMT Senescence / CELL_MATRIX_ADHESIONS
References
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
PMID:22118458
Integrin a2b1 predominantly binds to fibrillar collagen
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
References
em_emtc_emtc_re907( EMT Senescence ):
PMID:19161977
In the endoplasmic reticulum, integrin subunits find their binding partners and form heterodimers.
Monomeric integrins never reach the cell surface.
Integrins a1b1, a2b1, a10b1 and a11b1 bind to collagens
PMID:12297042
Cell adhesion to components of the ECM is important in the angiogenesis
PMID:2153105
PMID:2786007
PMID:7639691
PMID:10809728
integrins are receptors for different ECM proteins: Collagen 1, 4; Laminin 1, 8; Fibronectin and Vitronectin
PMID:7522194
PMID:16195317
Interactions between integrins and the ECM proteins result in focal cell adhesion and cytoskeleton remodeling.
→ em_emtc_emtc_s3291
→ em_emtc_emtc_s3293
+ COL4A1@Cytosol → COL4A1:a2b1*_a3b1*@Extracellular space
+ Laminin1*@Extracellular space → Laminin1*:a2b1*_a3b1*@Extracellular space
→ Cell-matrix adhesions@Extracellular space
→ Cell-matrix adhesions@Extracellular space